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Publications

Publications

RECENT PUBLICATIONS

Journal of Biomedical Science

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

Theranostics

Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer

PNAS

Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

Seminars in Cell & Developmental Biology

Cellular evasion strategies of Helicobacter pylori in regulating its intracellular fate.

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Communications Biology

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

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Cell Death and Disease

KDM4B is a co-activator of c-Jun and involved in gastric carcinogenesis

SELECTED PUBLICATIONS

1.  Liu JS, Fang WK, Yang SM, Wu MC, Chen TJ, Chen CM, Lin TY, Liu KL, Wu CM, Chen YC, Chuu CP, Wang LY, Hsieh HP, Kung HJ, and Wang WC* (2022). Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer. J Biomed Sci. 2022, 29, 29. doi: 10.1186/s12929-022-00812-3

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2.  Wu MJ, Chen CJ, Lin TY, Liu YY, Tseng LL, Cheng ML, Chuu CP, Tsai HK, Kuo WL, Kung HJ*, and Wang WC* (2021). Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics. 2021, 11(16): 7779–7796. doi: 10.7150/thno.58729

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3.  Tseng LLCheng HHYeh TSHuang SCSyu YYChuu CPYuh CHKung HJ, and Wang WC* (2020). Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proc Natl Acad Sci USA. 2020, 117(40): 24859-24866. doi: 10.1073/pnas.1919766117

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4.  Sit WY, Chen YA, Chen YL, Lai CH*, Wang WC* (2020). Cellular evasion strategies of Helicobacter pylori in regulating its intracellular fate. Semin Cell Dev Biol 101, 59-67. doi: 10.1016/j.semcdb.2020.01.007

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5.  Chen TJ, Wang HJ, Liu JH, Cheng HH, Hsu SC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ*, and Wang WC* (2019). PKM2 exon-10 tumor-related mutations: reduced allostery with increased nuclear translocation and association with KDM8. Commun. Biol. doi: 10.1038/s42003-019-0343-4. [Epub ahead of print],

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6.  Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ*, Chien S, and Wang WC* (2019). KDM4B is a co-activator of c-Jun and involved in gastric carcinogenesis. Cell Death Dis. 2019. 10(2): p. 68. 

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7.  Wang HJ, Pochapalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, and Kung HJ* (2019). KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in castration-resistant prostate cancer. Oncogene, 38(1), 17-32. doi: 10.1038/s41388-018-0414-x. [Epub ahead of print] 

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8.  Lai CH*, Huang JC, Cheng HH, Hsu HY, Huang MZ, Kao MC, Chen YA, Chu YT, Wu YF, Wu MC, Chen TJ, Zhang JR4, Wang HJ, and Wang WC* (2018). Helicobacter pylori cholesterol glucosylation modulates autophagy for increasing intracellular survival in macrophages. Cellular Microbiol. 20(12), e12947. Aug. 27. doi: 10.1111/cmi.12947.

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9.  Liu JS, Kuan YC, Tsou Y, Hsu WH, Yang MD, and Wang WC* (2018). Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine. Sci Rep 2018. 8(1): p. 2316.

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10.  Kuan YC, Thiruvengadam V, Lin JS , Liu JH, Chen TJ, Wu HM , Wang WC* and Chen LJ* (2018). Broad-specificity amino acid racemase, a novel non-antibiotic selectable marker for transgenic plants. Plant Biotech. Rep. https://doi.org/10.1007/s11816-018-0469-8S

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11.  Wang LY, Hung C., Chen YR, Yang JC, Wang J, Campbell M, Izumiya Y, Chen HW, Wang WC, Ann DK, and Kung, HJ* (2016). KDM4A Coactivates E2F1 to regulate the PDK-dependent metabolic switch between mitochondrial oxidation and glycolysis. Cell reports 16, 3016-3027.

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12.  Du SY, Wang HJ, Cheng HH, Chen SD, Wang LH, and Wang WC* (2016). Cholesterol glucosylation by Helicobacter pyloridelays internalization and arrests phagosome maturation in macrophages. J. Microbiol. Immunol. Infect. 49, 636-645. 10.1016/j.jmii.2014.05.011

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13.  Hung CL, Cheng HH, Hsieh WC, Tsai ZTY, Tsai HK, Chu CH, Hsieh WP, Chen YF, Tsou Y, Lai CH*, and Wang WC* (2015). The CrdRS two-component system responds to nitrosative stress in Helicobacter pylori. Mol Microbiol 97, 1128-1141. doi:10.1111/mmi.13089

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14.  Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM*, Kung HJ* and Wang WC*. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem2014(14), 57, 5975-5985. July 24, 

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15.  Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ*, and Wang WC* (2014). JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1a-mediated glucose metabolism. Proc Natl Acad Sci USA 111, 279-284

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* Corresponding Author

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